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Furthermore, the population of cancer stem cells (CSCs) within any tumor (now widely accepted to be the major source of resistance to conventional therapies), exhibits more pronounced iron dependency based on import and storage capacities compared to non-stem cancer cells [2, 3]

Zhao Y, Li H, Fang F, et al

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Zepbound coverage as of 2025-2026: Approximately 50-60% of commercial plans cover it under some conditions Coverage often requires prior authorization, BMI documentation, and proof of prior weight loss attempts Step therapy may require trying semaglutide or older agents first Medicare does not cover it for weight loss

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