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Although this evidence was not generated in a KOA population, it is highly relevant to obesity-related KOA because recurrence of weight gain may reduce the durability of pain relief, rehabilitation gains, and surgical optimization

Both confidence intervals cross 1.0, meaning neither result is statistically significant

Bold values indicate criteria contributing to the total Naranjo score

Understanding these mechanisms helps explain why treatments that improve metabolic and cardiovascular health may influence dementia risk

These medications influence appetite signals in the brain as well as digestion and blood sugar regulation