It is used in traditional Chinese medicine and in Ayurveda for chest pain, heart-related problems, dizziness, skin and eye disorders, to expel kidney stones, and as a diuretic and tonic
Diabetes 52(2):380386 Lau J, Bloch P, Schffer L, Pettersson I, Spetzler J, Kofoed J, Madsen K, Knudsen LB, McGuire J, Steensgaard DB, Strauss HM (2015) Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide
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Reddy's, Alkem, Biocon and OneSource Specialty Pharma are seen as better positioned to capitalise, aided by existing diabetes portfolios and partnerships.Ancillary beneficiaries are also expected, including Shaily Engineering Plastics, a key global supplier of pen devices used in injectable therapies, which could see meaningful demand growth as generic launches scale up.
This would be in line with preclinical observations that incretin receptor expression is down-regulated by exposure to high glucose, and improves once normoglycaemia is restored (48), and that dys-regulation of glycaemic control in otherwise healthy humans leads to impaired incretin actions (49)
Lixisenatide from Zealand Pharma was approved in June 2013, targeting type 2 diabetes