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This loss: Slows resting metabolism by 2-4% per decade Increases injury risk from reduced stability Accelerates bone density loss (muscle and bone health are linked) Contributes to the soft appearance even at a healthy weight Makes everyday activities progressively more difficult The Hormonal Challenge Testosterone, the primary muscle-building hormone, is present in women at about 1/10th the level of men

DPP-4 inhibitors are not recommended for cardiorenal risk reduction in high-risk individuals

Clues from laboratory models and clinical trials