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Of note, the concentration of these four metabolites in the 50 and 35x6 resistant groups was similar to those in the control group ( Figure 1B and Figure 2 )

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Any unexpected side effect, like water retention, could be a sign of contaminants triggering an off-target reaction

Hyperpigmentation occurs when patches of skin become darker than the surrounding areas, typically due to an excess production of melanin

Han C, Yu G, Mao Y, Song S, Li L, Zhou L, et al