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The Phase III trials have been testing tirzepatide as monotherapy, as an add-on to other treatments, and against established glucose-lowering drugs in people with T2D, as well as a weight-loss agent in people with diabetes and obesity
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Timeline : Noticeable improvements begin around 4-6 weeks
It is a key substrate for the synthesis of proteins and nucleotides, supporting cell growth and division
They prompt the pancreas to release more insulin when blood sugar rises and they blunt glucagon, the hormone that raises blood sugar a dual action that helps keep glucose steady
Moving forward, the results of the phase 3 SURPASS clinical trial program demonstrated that tirzepatide was as effective and safe as other anti-diabetic agents, such as semaglutide and dulaglutide (SURPASS-2) (SURPASS J-mono), long-acting insulin analogs (degludec and glargine) (SURPASS-3,4), and placebo (SURPASS-1) (SURPASS-5), in managing T2DM diabetes [65,66,67,68,69]
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