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The DRI modification makes the peptide backbone unrecognizable to endogenous aminopeptidases, carboxypeptidases, and endopeptidases, extending functional persistence from minutes to an estimated hours-to-days range

It is thanks to them that GHK-Cu can penetrate the deepest layers of the skin and has found such widespread use in cosmetics

For example, when the amount of mtROS produced by mitochondria changes due to hypoxia, mtROS enhances anaerobic respiration by stabilizing HIF-1 and up-regulating key enzymes of glycolysis such as lactate dehydrogenase, reduces the dependence of cells on OXPHOS during hypoxia, and reduces the further production of mtROS