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immediate labs if new medications are added or symptoms develop If ALT/AST rise above 2x upper limit of normal: Hold both agents, investigate, and reintroduce one at a time after normalization This schedule is conservative

However, combined efficacy and safety have only been examined in preclinical models, not in controlled human trials, so any pairing exists strictly within Research Use Only parameters

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Palma, M

Some foods that are low-histamine foods when fresh, will increase in histamines as they age

investigated the effect of epithalamin on the pineal and serum melatonin levels in elderly rats