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In a micellar environment GLP-1 assumes a structure with an Nterminal random coil segment and two helical segments separated by a linker region (112)

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P EG ylation : Increasing the molecular size of the drug to slow enzymatic degradation

704-8, DOI:10.1053/meta.2000.6250, PMID 10877193

Repeated injections in the same area can also cause localized tissue thickening or irritation

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