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Experts agree that nonmedical conditions such as availability, reimbursement policies, and costs may limit GLP1-RAs/SGLT2is combined therapy

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The Type 2 Diabetes Mellitus segment accounted for the maximum share of over 55.5% by application in 2025 due to the high global disease burden resulting in rising demand for efficacious therapies for glycemic control

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However, significant pain is uncommon, and most patients find the discomfort to be very manageable with prescribed medication and rest