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Adipose tissue dysfunction and altered systemic amino acid metabolism are associated with non-alcoholic fatty liver disease

Mitochondrial Dysfunction in Type 2 Diabetes and Obesity Well established data demonstrate that mitochondrial dysfunction, particularly as it relates to the processes of oxidative phosphorylation, is contributory to the development of encephalomyopathy, mitochondrial myopathy, and several age-related disorders that include neurodegenerative diseases, the metabolic syndrome, and diabetes

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GLP-1 medications slow gastric emptying and may affect GLP-1 receptors in taste buds and brain reward centres, potentially altering how sweet or fatty foods taste and how pleasurable they feel