Analysis of microglia progenitor recruitment from the circulation into the CNS using chimeric mice, obtained by parabiosis, indicated that recruitment from the periphery was very limited, even in mSOD mice [128]
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Strains with deletion of ZWF1 or RPE1 or TKL1 were more sensitive to the three tested oxidants than the wild type
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18, 19, 65, 66 Given that both carnitine deficiency and PPA can be detrimental to mitochondrial metabolism, it is possible that antibiotic overuse can cause these two effects to act synergistically to cause an acquired mitochondrial disorder, especially in genetically susceptible individuals