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While BW reduction likely contributes to improvements in conditions, such as hepatic steatosis or sleep apnea, GLP-1 RAs may also exert direct disease-specific effects, particularly through central mechanisms implicated in neurodegeneration and addiction [39]

The injection site should be changed to avoid irritation and ensure even absorption

In one, patients who lost 10.6% of their weight after 20 weeks of Wegovy were randomized to continue it or switch to placebo

In type 2 diabetes, insulin may be required on a long-term basis if other treatment options are ineffective or when insulin deficiency occurs