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doi:10.1093/eurheartj/ehv239 Franz MJ (2017): Weight Management: Obesity to Diabetes

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On average, adding GLP-1s for weight management can raise total pharmacy costs by about 25%, and in some high-utilization groups the increase can reach 1015%

Neural precursor cell expressed developmentally downregulated 4 (NEDD4), also known as NEDD4-1, is a HECT family E3 ligase with critical functions throughout life, including contributions to CNS development and injury repair [22-25]

The SURMOUNT-4 trial, which tested the maximum tolerated dose approach, showed a mean weight loss of 26% to 26.6% at the highest doses participants could tolerate

Step 6: Set clear stop criteria Establish specific triggers for discontinuing GLP-1 therapy