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doi: 10.1038/s41591-025-03799-0

It works by mimicking a naturally occurring hormone called glucagon-like peptide-1 (GLP-1), which targets areas of the brain that regulate appetite and food intake

Patients are typically encouraged to track: Weight trends over time, not just short-term changes

presented for research and educational use

Triple agonists like retatrutide 12 mg have demonstrated approximately 28.7% average weight loss over 68 weeks in Phase 3 trials