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DISCUSSION The mechanical and biochemical stress responses to exercise are complex and involve activation of the adenylate kinase system, generation of reactive oxygen species, inflammatory responses, and disruption to the contractile apparatus and cell membranes that ultimately contribute to fatigue by adversely impacting the metabolic, structural, and functional integrity of muscle
6 , eabe5310 (2020)
Lancet Oncol
Molecules, 27 (12), 3902
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