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Although clinical trials havent shown this to be significant with GLP-1s in particular, its best to use caution when taking any oral medication

Food and Drug Administration (FDA) publishes notices related to approved GLP-1 receptor agonists and compounding boundaries

USDA Economic Research Service

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It is worth noting that clinical studies and post-marketing surveillance have identified an increased risk of gallbladder-related events with GLP-1 receptor agonists, including semaglutide, though the mechanism for this association is not fully understood