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In line with the findings in humans, IGFBP-2 serum concentrations were markedly increased in nephrotic animals despite excessive urinary losses due to increased hepatic synthesis, whereas hepatic synthesis of IGFBP-3 was unchanged compared to controls

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SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM Trial Committees and Investigators

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These differences could be explained by the study design (retrospective observational study vs prospective randomized trial), selection bias (subjects from the real-world clinical practice are less selected than those included in a clinical trial), drug compliance (subjects enrolled in a clinical trial perform several on site evaluation in which compliance is verified by tablets accounting, while in clinical practice this is not done)