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When Trulicity is used with a sulfonylurea or insulin, the risk of hypoglycaemia increases
Promising safety profile: Early trials report tolerability comparable to incretin-based agents, though higher doses are associated with GI side effects (nausea, diarrhea, vomiting, constipation) Clinical Advantage over Others (Clinical Trial Evidence) Phase 2 obesity studies: At 48 weeks, retatrutide delivered weight reductions up to 24%, far exceeding results reported for monotherapy GLP-1 agents
But its certainly not yet proven. Other theories focus on the bigger health picture
These typically subside as your body gets used to the medication dosage
However, eating less will also mean less energy intake and less fuel for the body to convert into energy, which can lead to fatigue
