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Enhance cellular energy production for max physical output

Older adults People over 65 may be more susceptible to dehydration from GI side effects, and the consequences of dehydration (falls, kidney injury, confusion) are more serious in older populations

A key differentiator of Mardrigals resmetirom is that in a pivotal Phase 3 trial, it achieved both primary endpoints of NASH resolution and reduction in fibrosis (MAESTRO-NASH), the two liver histological improvement endpoints the FDA has proposed as reasonably likely to predict clinical benefit

Critics of the Bridge program say the 18-month window may not be enough to evaluate its effectiveness, as doctors and patients need time to adjust dosages to minimize side effects

Melanotan II still circulates in TRT circles for "aesthetic" purposes, but the side effects (nausea, spontaneous erections, darkening moles) and lack of safety data make it a hard pass unless you really want a tan that badly

This is most relevant at the thigh and abdomen in lean patients