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210,211 Mechanistically, IRF8 binds interferon-stimulated response elements in the promoters of key ATGs, including ATG5, ATG7, MAP1LC3B , and BECN1 , thereby increasing autophagosome formation

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The complex pathophysiology and heterogeneity of the disease raises the speculation that combined treatment will be required for many patients

The behavioral tests included the self-grooming test that served as a measure of repetitive behavior