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Research backs this up: when using GLP-1s to aid in weight loss, they were found to effectively reduce BMI, triglycerides, waist circumference, and total testosterone in people with PCOS, according to a 2024 meta-analysis in the Journal of Diabetes and its Complications

Metformin modulates mitochondrial function and mitophagy in peripheral blood mononuclear cells from type 2 diabetic patients

That feels misleading

A 4% drop in absolute LBM accompanying a 12% drop in body weight gives roughly 20% of weight loss as 'lean tissue.' Batsis reports closer to 35% and as Langer makes clear later in this piece, the gap between those numbers is partly explained by what DXA actually counts as 'lean

The effects of semaglutide are to increase insulin release, reduce glucagon release, delay gastric emptying, and reduce appetite

L-carnitine is also a well-known cognitive enhancer, improving your brain