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Most of the GSH used for detoxification is produced in the liver and excreted in plasma in the blood stream

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Where F a is the fraction of the compound (inhibitor) absorbed, F g is the intestinal availability, k a is the absorption rate constant, Q h is the hepatic blood flow rate, which is determined as 97 L/h (70 kg body weight), and R B is the blood-to-plasma concentration ratio

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