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Medical necessity typically requires documented obesity (BMI 30) plus at least one weight-related comorbidity such as type 2 diabetes, hypertension, sleep apnea, nonalcoholic fatty liver disease, or cardiovascular disease
Juneja K et al
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The SUSTAIN 6 trial found that once-weekly subcutaneous semaglutide reduced the risk of MACE by 26% compared to placebo over a 2-year period
It mimics a gut hormone called GLP-1, which communicates with the brains appetite centre to reduce hunger and food noise (the constant pre-occupation with food, even if not physically hungry)
Retatrutide's Triple-Receptor Profile Retatrutide's glucagon receptor activity accelerates lipolysis and raises resting energy expenditure
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