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If orforglipron performs as expected, it could greatly reduce the demand for injections, expand access for those hesitant about needles, and introduce more competition in the GLP-1 space, which could eventually lead to lower prices

The combination of mSEPT9-AFP-PIVKA-II is optimal compared to any single marker and may be useful for opportunistic screening of HCC in the cirrhotic population (Zheng et al., 2023)

26,27 The rate of gastric emptying is particularly relevant as it is a major determinant of post-meal glucose levels in people with and without diabetes and may, hence, influence treatment regimens

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