Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease
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Many of the mechanisms have been elucidated by the Jaeschke group in Kansas [18,36,37]
Glutathione synthetase deficiency is the most frequently recognized disorder and, in its severe form, it is associated with hemolytic anemia, metabolic acidosis, 5-oxoprolinuria, central nervous system (CNS) damage and recurrent bacterial infections
The largest study of this type was published in 2023 in JAMA Internal Medicine
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