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Additionally, the medication has been associated with improvements in various cardiometabolic parameters, such as blood pressure, lipid profiles, and glycemic control
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This dual agonism allows the drug to lower glucose levels and reduce weight, but the side effects reported for Mounjaro are similar to other GLP-1 agonists
Glucagon typically raises blood sugar, but when combined with GLP-1 agonism, the net effect is a significant boost in energy expenditure
383,384 Importantly, the activation of AMPK reduces the expression of phosphoglycerate mutase 5 (PGAM5), which plays a promotive role in cell necrosis by contributing to mitochondrial dysfunction and the production of reactive oxygen species (ROS)
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