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88,90,92 RB1 loss is seen in approximately 10% of cases in mCRPC, and has been associated with poor prognoses (Fig

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Here, homocysteine is converted to the amino acid cysteine via two vitamin B 6 (PLP)-dependent enzymes: Cystathionine -synthase catalyzes the condensation of homocysteine with serine to form cystathionine, and then converted by cystathionine -lyase into cysteine, -ketobutyrate, and ammonia

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