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Heat and light are the real enemies Temperature swings and UV light speed up peptide breakdown

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Visual inspection checklist: Clarity : The solution should be completely clear, not cloudy, hazy, or opaque Colour : Should be colourless or almost colourless Particles : No visible particles, flakes, crystals, or sediment should be present Discolouration : Any unusual colouration indicates degradation If you observe any of these abnormalities, do not use the pen

Competing interests The authors declared no competing interests