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Medical Hypotheses, 80 (5), 633636
In support of their role in weight management, GLP-1Rs are expressed in adipose tissue, where they regulate the proliferation of pre-adipocyte cells and lipid homeostasis (27)
Older patients and those experiencing hormonal transitions may need longer treatment courses or ongoing maintenance therapy because their underlying metabolic environment is less forgiving of medication withdrawal
Although, there are no human data describing the effect of GIP activity on memory and other cognitive functions, several animal studies have shown that activation of the GIP receptor has a profound effect on neuronal plasticity (108)
Sivakumar, M., Muthu, Y
It is important to distinguish between GLP-1 receptor agonist medications (such as semaglutide and liraglutide, which are licensed pharmaceutical treatments) and probiotic supplements marketed with claims about GLP-1 modulation
