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19,20 Retatrutide, a triple GLP-1/GIP/glucagon agonist, has demonstrated the greatest reported efficacy to date, with weight loss reaching approximately 24.2% in adult clinical trials
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However, recent evidence that glucagon increases energy expenditure independently of BAT activation in humans [64] indicates that alternative mechanisms such as futile substrate cycling [65] may underlie glucagons thermogenic properties
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One clinical study that followed 2,000 people who combined semaglutide with a healthy lifestyle lost between 15% to 20% of their body weight after 68 weeks
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