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MT-1 cannot produce visible pigmentation without UV stimulus to activate tyrosinase

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Neuromolecular Med 15:102114

The cautions are the ones already covered

Current NICE guidance continues to position metformin as the initial treatment for most adults with type 2 diabetes, reserving GLP-1 agonists for specific situations rather than universal first-line use

The problem with lowering the dose of insulin in combination with having a SGLT-2 inhibitor on board is that the levels of ketones start to rise and push some people to DKA, a life-threatening complication, Mathieu said, adding that DKA primarily occurred in people who had a lower body weight, were on insulin pumps, or had a pump catheter obstruction