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Cohen suggested that SMD values above 0.2 be considered small, SMD values above 0.5 considered medium-sized, and SMD values above 0.8 considered large (36, 37)

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G protein-coupled receptors (GPCRs) represent a prevalent area of research in the pharmaceutical sciences, with these receptors activating diverse signaling pathways in response to various ligands and depending on the specific tissue type, as illustrated by the following examples: When targeting G-protein-coupled receptors (GPCRs), alternative pathways such as fatty acid -oxidation (FAO) and other alternative pathways of glutamine metabolism provide nutrient support to cancer cells

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Avoidance of hypoglycemia, especially in comparison with sulphonylureas and insulin, is likely to be the major advantage of these newer treatments for type 2 diabetes

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