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The group taking 0.5mg of tesofensine experienced an average weight loss of 13-14kg during this period, which was significantly more than the placebo group

However, this pathway is reported to be inactive in most tissues, and in the few tissues in which it is active, its function is reduced in tumours from the corresponding tissue 16

Diabetic Retinopathy (Eye Disease Caused by Diabetes): Semaglutide can sometimes lead to a worsening of diabetic retinopathy, particularly during rapid glucose lowering

The source of this claim has not been published in a peer-reviewed journal