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Bonifacio A et al
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The washout period represents a brief cessation, and while 25 to 30 days is not long enough for full weight regain, it is enough for 2 to 5 pounds of regain in most people
As evidence accrues, we, and others, will monitor what it means for the impact of GLP-1 medications on SMM, but so far we have not seen any compelling clinical data (although new systematic reviews and meta analyses have been proposed ) that GLP-1 medications lead to pathological skeletal muscle mass loss relative to what has been demonstrated and observed in other weight loss interventions
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For those planning to taper their medication eventually, our guides on weaning off tirzepatide and managing semaglutide withdrawal include nutrition strategies for maintaining weight loss as appetite returns
