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Semaglutide is an FDA-approved weight loss injection
The standard administration route for most peptides including Retatrutide
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Ten of the 26 proteins whose regulation was not correlated with weight loss in the clinical trial (29) were also modulated in the GAN DIO-MASH mouse, supporting conserved semaglutide-responsive pathways in the model and suggesting that additional mechanisms may contribute to the hepatic effects of semaglutide in MASH
Additionally, shorter study duration, given constant weight loss, was correlated with a greater decrease in total GLP-1 in RCTs
