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00:10:17 Vickie Danaher The most common issues are stomach-related things like nausea, diarrhea, abdominal discomfort, and sometimes vomiting, especially during dose titration

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Many sulfonamide derivatives of metformin exerted cytotoxicity in human breast cancer cells (MCF-7 or MDA-MB-231, or both) induced particularly by methylated phenyl sulfonamides and was associated with their ability to arrest the cell cycle in the G0/G1 phase and subsequently to cause apoptosis (Torunoglu et al., 2023)

Some details may have changed since that time

Of 984 patients, 29.2% had hand-foot skin reactions