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Address correspondence to: Yingjie Zhu, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, 518055 Gunagdong, China

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Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition

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Under conditions of metabolic stress, it migrates to the cell nucleus, where it activates a suite of genes governed by AMPK (AMP-activated protein kinase), the master cellular energy sensor