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Figure 1: A metabolic use-case comprehensive patient journey view with taXonomy Pathways In clinical trials, GLP-1 drugs showed high adherence (over 85% of patients stayed on therapy), yet real-world use tells a different story: one large study found only 32% of obese patients remained on a GLP-1 therapy after one year, with just 27% meeting standard adherence thresholds

Could the weight loss from Retatrutide be the reason for any changes in hormone levels

Youre addressing multiple mechanisms simultaneously

Key monitoring strategies used in these trials include: Regular laboratory assessments (liver enzymes, lipase and amylase, renal function markers, HbA1c and glucose) Renal function monitoring, particularly if significant gastrointestinal adverse effects occur and dehydration is a concern Cardiovascular monitoring, including resting heart rate and blood pressure GLP-1 and glucagon receptor agonism can increase resting heart rate, which requires careful evaluation in those with pre-existing cardiac conditions Calcitonin measurement and thyroid ultrasound where specified by trial protocol, to monitor for any signal related to thyroid C-cell changes (noting that routine thyroid function tests are not the specific safety assessment for this risk) Body composition assessments using imaging tools, which are research-protocol-specific rather than routine clinical monitoring, to evaluate changes in lean muscle mass versus fat mass Patient-reported outcome measures to capture quality-of-life changes and symptom burden over time Ophthalmic assessments in participants with pre-existing diabetic retinopathy, given the potential for early worsening with rapid glycaemic improvement The glucagon receptor component of retatrutide introduces additional monitoring considerations

Deciding on a new therapy can feel like a big step, but understanding who its designed for can make the choice much clearer

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