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This triggers the MAPK cascade, such that Ras-GTP activates Raf [also called MAPK kinase kinase (MAPKKK)], which in turn activates MEK1/2 [MAPK kinase (MAPKK)]

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Psoriasis is fundamentally an immune dysregulation disorder

Because these symptoms can be subtle or overlap with other health issues, they often go undiagnosed for extended periods

Both contribute to the normal protection of cells from oxidative stress and the normal function of the immune system