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A 2022 paper in the International Journal of Molecular Sciences characterised effects on proliferative activity and inflammatory pathways in monocyte/macrophage THP-1 cell research (PMID 35408963)
Risk of miscarriage and birth defects Both semaglutide and tirzepatide have been shown to cause miscarriage and birth defects in pregnant lab animals (rats and rabbits) at doses equivalent to what is used for humans
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Contact your doctor if you do not experience increased muscle strength and decreased fat mass within 3 to 6 months
Earlier SURMOUNT-1 data further reinforced these outcomes, with tirzepatide demonstrating weight loss of up to 22.5% of body weight over 72 weeks, the highest ever recorded for a pharmacological weight loss therapy at that time
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