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Dosing fundamentals Administration: Once weekly subcutaneous injection Same day each week (consistency matters) Preferably at the same time of day Half-life: Approximately 6 days, supporting weekly dosing Dose escalation: Every 4 weeks, unless: Side effects require holding current dose Individual tolerance suggests faster/slower progression Healthcare provider recommends adjustment Clinical trial doses tested The Phase 2 obesity trial tested multiple dosing arms: Key insight: 8 mg produces nearly the same results as 12 mg with fewer side effectsmaking it a potential "sweet spot" for many users
Fluid Retention on TRT: The Mechanism Testosterone aromatizes -- it converts to estradiol via the aromatase enzyme, particularly in adipose (fat) tissue
Long-acting GLP-1 receptor agonists provide sustained receptor activation and clinically meaningful improvements in glycaemic control and weight in eligible patients, as recognised in NICE guidance (NG28) for type 2 diabetes management
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Patients who implement these dietary and activity changes typically experience more substantial results than those relying on medication alone
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