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After a 30-min stabilization incubation, PBS (without IBMX) and 100 M 3-isobutyl-1-methylxanthine (with IBMX) (Sigma Chemicals, St Louis Mo) was added and incubated for 60 min so that each rat served as its own control

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In clinical trials last year, patients taking the highest dose of semaglutide lost an average of 15% of their body weight compared to 21% on the highest dose of tirzepatide

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