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Third, since conditional Slc7a11 knockout mice were unavailable, our in vivo analysis relied on pharmacologic inhibition of the cystine/glutamate transporter and cannot completely exclude off-target effects of sulfasalazine or the contribution of other cell types beyond dendritic cells and fibroblasts in glutathione synthesis
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One notable example is this meta-analysis of MTHFR case-control studies, which raises a serious concern: What if only Mendelian randomization studies that found an association have been published
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