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Kidney Int 83:517523 Lewis EJ, Hunsicker LG, Clarke WR, Berl T, Pohl MA, Lewis JB et al (2001) Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
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The cleavage of the signal peptide from the pre-proinsulin leads to the formation of pro-insulin, which is subsequently packaged by the Golgi's secretory granules and later cleaved by additional proteins to produce insulin [1]