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A study showed that people with diabetic neuropathy got better symptoms with regular B12 shots

The AMA found improper coding of therapeutic injections resulted in over $500 million in denied claims in 2023

It is going to take weeks of injections to really feel the difference in your mood and energy levels

This includes: Patients with malabsorption issues due to gastrointestinal disorders Individuals with pernicious anemia or other conditions that impair B12 absorption Cases where a rapid increase in B12 levels is necessary In these cases, IV delivery gets B12 straight into the blood

B12 might be part of a multivitamin or a standalone supplement

What's missing: No human pharmacokinetic data No human safety data No optimal dose for humans (mouse 20mg/kg = ~150mg in a 75kg human if dose-equivalent, but mouse-to-human scaling for small molecules is unreliable) No drug interaction data No long-term safety data Buyers in this category are doing biohacker-tier self-experimentation with limited data