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This explains why many oral vitamin B12 supplements contain very high dosages of vitamin B12: most are designed to cover the RDA via passive diffusion

At Perfect B, dose adjustments are made at the mid-cycle check-in

In terms of weight loss, if you have a vitamin B12 deficiency, which is likely, you will lose some of the vitamin B12 shot in the first 48 hours, but at least 50% of it will be stored in your liver