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The SUSTAIN-6 trial, which evaluated semaglutide in patients with type 2 diabetes at high cardiovascular risk, identified a statistically significant increase in diabetic retinopathy complications in the semaglutide group compared to placebo
They also observed less response to GLP-1 in the pancreas and in the gut of these mice, indicative of GLP-1 resistance, yet there was no change in the expression of GLP-1 receptors in these tissues
These unique properties give rise to the expansion of MOFs developed from their traditional applications like gas adsorption and catalysis to their modern applications in drug delivery systems, cancer therapy, biomedical imaging, antimicrobial therapy, and tissue engineering
Miller et al., 2022)
These factors alter myocardial mitochondrial function, induce apoptosis, and impact cardiac contractility [5]
Back Nauck, MA, Klein, N, rskov, C, et al (Aug 1993) 'Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients', Diabetologia , 36/8, 741-4
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