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Nutritional deficiencies There are other nutrients that work alongside COQ10 and glutathione and to help them continue to do their job (remember the baton analogy from above!)
Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes (free full text)
E., Crabb, B
Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization
Inflammatory cytokines and innate immune response
Things that might lead to dose changes include how bad the deficiency was, if there are nerve symptoms, if theres ongoing trouble absorbing nutrients, and how each patient responds
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