Reduced Formation of 1-Methylnicotinamide Researchers use reduced 1-methylnicotinamide as a pharmacodynamic marker that NNMT activity has been inhibited
High-dose B12 therapy is usually safe
When these B vitamins are low, homocysteine rises, and elevated homocysteine is associated with increased clotting risk
This is particularly beneficial in places like Australia, where cost-efficiency is as much a priority as it is a necessity
Chan School of Public Health
[10] [4] Patients should contact their GP if they experience persistent or severe side effects, signs of allergic reaction (facial swelling, difficulty breathing, severe rash), or if symptoms of B12 deficiency (such as neurological symptoms, severe fatigue, or glossitis) do not improve after several weeks of supplementation